Journal
TRENDS IN IMMUNOLOGY
Volume 41, Issue 2, Pages 157-171Publisher
CELL PRESS
DOI: 10.1016/j.it.2019.12.003
Keywords
-
Categories
Funding
- NSF IOS [1457055]
- NIH [DK043351, GM101056]
- Direct For Biological Sciences [1457055] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems [1457055] Funding Source: National Science Foundation
Ask authors/readers for more resources
Microphthalmia/TFE (MiT) transcription factors (TFs), such as transcription factor EB (TFEB) and transcription factor E3 (TFE3), are emerging as key regulators of innate immunity and inflammation. Rapid progress in the field requires a focused update on the latest advances. Recent studies show that TFEB and TFE3 function in innate immune cells to regulate antibacterial and antiviral responses downstream of phagocytosis, interferon (IFN)-gamma, lipopolysaccharide (LPS), and adenosine receptors. Moreover, overexpression of TFEB or TFE3 can drive inflammation in vivo, such as in atherosclerosis, while in other scenarios they can perform anti-inflammatory functions. MiT factors may constitute potential therapeutic targets for a broad range of diseases; however, to harness their therapeutic potential, sophisticated ways to manipulate MiT factor activity safely and effectively must be developed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available