Journal
TRENDS IN IMMUNOLOGY
Volume 41, Issue 2, Pages 126-140Publisher
CELL PRESS
DOI: 10.1016/j.it.2019.12.002
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Funding
- National Institutes of Health [GM128943-01, CA184043-03]
- V Foundation for Cancer Research [V2016-006]
- Pew Stewart Scholars Program for Cancer Research
- Leona M. and Harry B. Helmsley Charitable Trust
- Salk Institute T32 Cancer Training Grant [T32CA009370]
- NIGMS NRSA [F32 GM128377-01]
- University of California, San Diego Institutional National Research Service Award [(1-32) 5T32DK007541-32]
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Epigenetic regulation plays an important role in controlling the activation, timing, and resolution of innate immune responses in macrophages. Previously, SWI/SNF chromatin remodeling was found to define the kinetics and selectivity of gene activation in response to microbial ligands; however, these studies do not reflect a comprehensive understanding of SWI/SNF complex regulation. In 2018, a new variant of the SWI/SNF complex was identified with unknown function in inflammatory gene regulation. Here, we summarize the biochemical and genomic properties of SWI/SNF complex variants and the potential for increased regulatory control of innate immune transcriptional programs in light of such biochemical diversity. Finally, we review the development of SWI/SNF complex chemical inhibitors and degraders that could be used to modulate immune responses.
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