Journal
TRENDS IN IMMUNOLOGY
Volume 41, Issue 1, Pages 61-76Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2019.11.007
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Funding
- Wellcome Trust [102705, 097377]
- MRC Centre for Medical Mycology
- University of Exeter [MR/N006364/1]
- National Commission for Scientific and Technological Research (CONICYT), Chile
- MRC [MR/N006364/1, MR/N006364/2] Funding Source: UKRI
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Fungi can cause disease in humans, from mucocutaneous to life-threatening systemic infections. Initiation of antifungal immunity involves fungal recognition by pattern recognition receptors such as C-type lectin receptors (CLRs). These germline-encoded receptors trigger a multitude of innate responses including phagocytosis, fungal killing, and antigen presentation which car also shape the development of adaptive immunity. Recently, studies have shed light on how CLRs directly or indirectly modulate lymphocyte function. Moreover, CLR-mediated recognition of commensal fungi maintains homeostasis and prevents invasion from opportunistic commensals. We present an overview of current knowledge of antifungal T cell immune responses, with emphasis on the role of C-type lectins, and discuss how these receptors modulate these responses at different levels.
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