Journal
TRENDS IN IMMUNOLOGY
Volume 40, Issue 12, Pages 1120-1133Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2019.10.008
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Funding
- American Association for the Study of Liver Diseases (AASLD) Pinnacle Research Awards
- CPRIT New Investigator Recruitment Award [RR180014]
- University of Texas System Rising STARs Award
- UT Southwestern Circle of Friends Award in Cancer Research
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Inflammation benefits the host by promoting the elimination of invading pathogens and clearance of cellular debris after tissue injury. Inflammation also stimulates tissue repair and regeneration to restore homeostasis and organismal health. Emerging evidence suggests that mitochondrial DNA (mtDNA), the only form of non-nuclear DNA in eukaryotic cells, is a major activator of inflammation when leaked out from stressed mitochondria. Here, we review the current understanding on the role of mtDNA in innate immunity, discussing how dysregulated mtDNA metabolism can promote chronic inflammation and disease progression.
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