Journal
TRENDS IN CELL BIOLOGY
Volume 30, Issue 1, Pages 60-73Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2019.10.003
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Funding
- Dutch Cancer Society
- European Research Council [242958]
- EU [608180]
- Netherlands Organization for Scientific Research (NWO) VICI [91815604]
- Netherlands Organization for Scientific Research (NWO) ECHO [711.013.012]
- Netherlands Organization for Scientific Research (NWO) ZonMW TOP [91218050]
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Intestinal organoids grown from adult stem cells have emerged as prototype 3D organotypic models for studying tissue renewal and homeostasis. Owing to their strict dependence on Wnt signaling, intestinal organoids offer an unprecedented opportunity to examine Wnt pathway regulation it normal physiology and cancer. We review how alterations in growth factor dependency and orga noid morphology can be exploited to identify Wnt signaling mechanisms, characterize mutated pathway components, and predict responses of patient-derived tumors to targeted therapy. We discuss current deficits in the understanding of genotype-phenotype relationships that are to be considered when interpreting mutation-induced changes in organoid morphology.
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