Journal
CANCER LETTERS
Volume 382, Issue 1, Pages 44-52Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2016.08.020
Keywords
Fucoidan; Angiogenesis; VEGF; Lung cancer
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Funding
- National Natural Science Foundation of China (NSFC) in China [31230022]
- Shanghai Foundation for Outstanding Academic Leaders in China [16XD1404500]
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Fucoidan may inhibit angiogenesis. However, its functional target molecule and the underlying mechanism are still vague. In the present study, we showed that sulfated fucoidan FP08S2 from Sargassum fusiforme inhibited tube formation as well as migration and invasion of human microvascular endothelial cells (HMEC-1). In addition, FP08S2 was confirmed to disrupt VEGF-induced angiogenesis both in vitro and in vivo. Further study indicated that FP08S2 could bind to both VEGF and VEGFR2 to interfere with VEGF-VEGFR2 interaction. Moreover, VEGFR2/Erk/VEGF signaling pathway was blocked by FP08S2 in HMEC-1 cells. Importantly, FP08S2 impeded the growth and microvessel formation of A549 cancer cell xenograft in nude mice. These results suggested that FP08S2 presented remarkable anti-angiogenic activity via blocking VEGF signaling and could be a potential novel leading compound to inhibit lung cancer cell growth. (C) 2016 Published by Elsevier Ireland Ltd.
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