Journal
TRENDS IN BIOTECHNOLOGY
Volume 38, Issue 6, Pages 606-622Publisher
CELL PRESS
DOI: 10.1016/j.tibtech.2019.12.023
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Funding
- UK Biotechnology and Biological Sciences Research Council (BBSRC) [BB/K020633/1, BB/l013789/1-Phyconet PHYCBIV-13, PHYCBIV-28]
- Engineering and Physical Sciences Research Council (EPSRC) [EP/E036252/1, DTA 1912024]
- BBSRC [BB/K020633/1] Funding Source: UKRI
- EPSRC [EP/E036252/1] Funding Source: UKRI
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A switch from a petroleum-based to a biobased economy requires the capacity to produce both high-value low-volume and low-value high-volume products. Recent evidence supports the development of microalgae-based microbial cell factories with the objective of establishing environmentally sustainable manufacturing solutions. Diatoms display rich diversity and potential in this regard. We focus on Phaeodactylum tricornutum, a pennate diatom that is commonly found in marine ecosystems, and discuss recent trends in developing the diatom chassis for the production of a suite of natural and genetically engineered products. Both upstream and downstream developments are reviewed for the commercial development of P. tricornutum as a cell factory for a spectrum of marketable products.
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