Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 45, Issue 2, Pages 96-107Publisher
CELL PRESS
DOI: 10.1016/j.tibs.2019.11.003
Keywords
-
Categories
Funding
- NSERC (Natural Sciences and Engineering Research Council of Canada)
Ask authors/readers for more resources
During interphase, filamentous actin, microtubules, and intermediate filaments regulate cell shape, motility, transport, and interactions with the environment. These activities rely on signaling events that control cytoskeleton properties. Recent studies uncovered mechanisms that go far beyond this one-directional flow of information. Thus, the three branches of the cytoskeleton impinge on signaling pathways to determine their activities. We propose that this regulatory role of the cytoskeleton provides sophisticated mechanisms to control the spatiotemporal output and the intensity of signaling events. Specific examples emphasize these emerging contributions of the cytoskeleton to cell physiology. In our opinion, further exploration of these pathways will uncover new concepts of cellular communication that originate from the cytoskeleton.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available