Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 45, Issue 1, Pages 58-75Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2019.08.002
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Funding
- Singapore National Medical Research Council [NMRC/CIRG/1373/2013, NMRC/CIRG/1430/2015]
- Singapore Ministry of Education (MOE) [MOE2018-T2-1-060]
- National University of Singapore (NUSMed) post-doctoral fellowship
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Mitophagy refers to the process of selective removal of damaged or superfluous mitochondria: via the autophagy/lysosome pathway. In the past decade the molecular mechanisms underlying mitophagy have been extensively studied. It is now well established that the key mitophagy machinery undergoes extensive post-translational modifications (PTMs) such as phosphorylation, dephosphorylation, ubiquitination/deubiquitination, and acetylation/deacetylation that involve an array of enzymes including protein kinases/phosphatases, E3 ligases/deubiquitinases, acetyl transferases/deacetylases. In this review we provide a systematic summary of these key PTMs , and discuss the effectors and the functional implications of such PTMs in mitophagy-related diseases. Understanding PTM of the mitophagy machinery offers a unique window of opportunity for the discovery of novel mitophagy interventional strategies and for the control of mitophagy-related diseases.
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