Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 44, Issue 12, Pages 993-995Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2019.10.001
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- Centre for Brain Research (CBR) [DST/INSPIRE/04/2018/000190]
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Frottin et al. uncovered a role for the nucleolus as a key quality control compartment that regulates misfolded nuclear proteins. This nonmembrane compartment achieves this by forming liquid-like protein condensates that aid protein refolding in a heat-shock protein (Hsp)70-dependent manner. This liquid-liquid phase separation (LLPS)-mediated nuclear quality control mechanism is perturbed during neurodegeneration.
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