Journal
CANCER LETTERS
Volume 380, Issue 1, Pages 253-256Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2015.10.022
Keywords
Myeloid-derived suppressor cells; Tumor microenvironment; angiogenesis; immune suppression; M-MDSC; PMN-MDSC
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Funding
- Intramural Research Program at the NCI, NIH
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Myeloid derived suppressor cells (MDSCs) are a group of immature myeloid cells accumulated in most cancer patients and mouse tumor models. MDSCs suppress host immune response and concurrently promote tumor angiogenesis, thereby promote tumor growth and progression. In this review, we discuss recent progresses in expansion and activity of tumor MDSCs, and describe new findings about immunosuppressive function of different subtypes of MDSCs in cancer. We also discussed tumor angiogenic activities and pro-tumor invasion/metastatic roles of MDSCs in tumor progression. Published by Elsevier Ireland Ltd.
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