Journal
CANCER LETTERS
Volume 380, Issue 1, Pages 237-242Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2015.10.005
Keywords
Metastasis; Microenvironment; Dispersal; Transmogrification; Epithelial-mesenchymal-transition; Homing
Categories
Funding
- NCI [U54CA143803, CA163124, CA093900, CA143055]
- Provost's Undergraduate Research Award at Johns Hopkins University
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The process by which prostate cancer cells non-randomly disseminate to the bone to form lethal metastases remains Unknown. Metastasis is the ultimate consequence of the long-range dispersal of a cancer cell from the primary tumor to a distant secondary site. In order to metastasize, the actively emigrating cell must move. Movement ecology describes an individual's migration between habitats without the requirement of conscious decision-making. Specifically, this paradigm describes four interacting components that influence the dynamic process of metastasis: (1) the microenvironmental pressures exerted on the cancer cell, (2) how the individual cell reacts to these external pressures, (3) the phenotypic switch of a cell to gain the physical traits required for movement, and (4) the ability of the cancer cell to navigate to a specific site. A deeper understanding of each of these components will lead to the development of novel therapeutics targeted to interrupt previously unidentified steps of metastasis. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.
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