Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 122, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2019.115706
Keywords
Biosensor; Catalytic hairpin assembly (CHA); Cell imaging; Entropy-driven catalysis (EDC); Fluorescent; Hybridization chain reaction (HCR); RNA-cleaving DNAzyme; Nucleic acid circuits (NACs); Strand displacement amplification (SDA)
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Funding
- National Key R&D Program of China [2018YFC1602306]
- National Natural Science Foundation of China (NSFC) [21777013]
- Recruitment Program of Global Young Experts (Thousand Talents Program)
- Fundamental Research Funds for the Central Universities [DUT17RC(3)040, DUT19TD20]
- LiaoNing Revitalization Talents Program [XLYC1807080]
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Integrating nucleic acid circuits (NACs) with functional DNA probes has emerged as a promising platform in the field of biosensing, offering a facile and versatile way of detecting a wide variety of intracellular analytes in live cells. This methodology combines the power of NACs as signal amplifiers and the functional versatility of DNA probe as a molecular recognition. Very recently, several elegant NACs uniquely applicable to fluorescent biosensing systems have been reported to achieve the intracellular imaging of diverse targets. This review serves to highlight recent achievements in this emerging research field and provides a future perspective on where the field is headed. (C) 2019 Elsevier B.V. All rights reserved.
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