Journal
CANCER INVESTIGATION
Volume 34, Issue 9, Pages 415-423Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357907.2016.1222416
Keywords
Activin; biomarkers; bone metastasis; breast cancer; cathepsin L; cystatin C; follistatin; tumor markers
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Funding
- Italian Ministry of University and Research (MIUR) [2005-ATE-0664, ORPA052247, 2007-ATE-0681, ORPA07MN29]
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This study was directed to assess the clinical impact of the circulating cathepsin L, cystatin C, activin A, and follistatin in breast cancer patients. The serum concentrations of these molecules were determined by immunoenzymatic assays, and their association with some clinico-pathological parameters of breast cancer progression was evaluated. Our results identified cystatin C and activin A as predictive markers for the presence of breast cancer and bone metastasis, respectively. Therefore, these proteins may have a clinical role as circulating biomarkers in the diagnosis and therapeutic monitoring of breast cancer patients.
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