Pharmacological and toxicological aspects of carbon nanotubes (CNTs) to vascular system: A review

Carbon nanotubes (CNTs) are novel carbon based nanomaterials (NMs) that could be used in many areas ranging from electronics to biotechnology. The present review summarized pharmacological and toxicological aspects of CNTs to vascular systems, because the vascular systems are important targets for CNTs during manufacturing process, daily contact and biomedical uses. Functionalized CNTs could be used as novel nanoplateforms to regulate angiogenesis for cancer therapy, as well as nanocarriers to cross blood brain barrier (BBB), one of the major obstacles to prevent the entering of therapeutic substances into brains. However, it has also been shown that inhalational or intravenous contact with CNTs might induce adverse vascular effects, such as progression of atherosclerotic plaque, vasomotor dysfunction, and changes of blood pressure and/or heart rate in laboratory animals, although currently there are only limited reports obtained from CNT-exposed human beings and the results are inconclusive. The mechanisms associated with the vascular toxicity of CNTs remain poorly understood, and it appears that multiple signaling pathways are likely to be involved. The toxicity of CNTs to vascular systems might be reduced by controlling the physicochemical properties of CNTs, particularly lengths, diameters and surface chemistry. At present, the beneficial and adverse effects of CNTs to vascular systems are still largely unknown and require further extensive studies.