Journal
CANCER IMMUNOLOGY IMMUNOTHERAPY
Volume 66, Issue 8, Pages 959-968Publisher
SPRINGER
DOI: 10.1007/s00262-016-1929-z
Keywords
Tumor microenvironment; Schwann cell; Nervous system; Neuroinflammation; Regulatory myeloid suppressor cells
Categories
Ask authors/readers for more resources
Cancerous cells must cooperate with the surrounding stroma and non-malignant cells within the microenvironment to support the growth and invasion of the tumor. The nervous system is a component of every organ system of the body, and therefore, is invariably at the front line of the tumor invasion. Due to the complexity of the nervous system physiology, this review separately discusses the contributions of the central and peripheral nervous systems to the tumorigenesis and tumor progression. We further focus the discussion on the evidence that Schwann cells aid in tumor growth and invasion. Schwann cells, a largely unexplored element of the tumor microenvironment, may participate in the creation of tumor-favorable conditions through both bi-directional interaction with cancer cells and the facilitation of the immune-suppressive microenvironment through the mechanism of neural repair and immunomodulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available