Journal
CANCER IMMUNOLOGY IMMUNOTHERAPY
Volume 65, Issue 12, Pages 1433-1450Publisher
SPRINGER
DOI: 10.1007/s00262-016-1895-5
Keywords
Chimeric antigen receptor; CAR; Clinical trial; Adoptive cell therapy; T cell
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Funding
- Deutsche Forschungsgemeinschaft, Bonn, Germany
- Deutsche Krebshilfe, Bonn, Germany
- Deutsche Jose Carreras-Leukamie Stiftung, Munich, Germany
- Else Kroner-Fresenius Stiftung, Bad Homburg v.d.H., Germany
- Fortune Program of the Medical Faculty of the University of Cologne, Cologne, Germany
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In recent years, cancer treatment involving adoptive cell therapy with chimeric antigen receptor (CAR)-modified patient's immune cells has attracted growing interest. Using gene transfer techniques, the patient's T cells are modified ex vivo with a CAR which redirects the T cells toward the cancer cells through an antibody-derived binding domain. The T cells are activated by the CAR primary signaling and costimulatory domains. Such second generation CAR T cells induced complete remission of B cell malignancies in the long-term. In this fast-moving field with a growing number of engineered T cell products, we list about 100 currently ongoing trials here that involve CAR T cells targeting hematopoietic malignancies and solid cancer. Major challenges in the further development of the therapy are briefly discussed.
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