Journal
THERIOGENOLOGY
Volume 150, Issue -, Pages 41-47Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.theriogenology.2020.01.066
Keywords
Proteomics; Seminal plasma; Spermatozoa; Cryopreservation; Fertility; Pig
Categories
Funding
- European Regional Development Fund
- Spanish Government [MINECO-FEDER AGL2015-69738-R]
- Seneca Foundation of Murcia [19892/GERM/15]
- Research Council FORMAS, Stockholm, Sweden [2017-00946]
- Swedish Research Council [2017-00946] Funding Source: Swedish Research Council
- Formas [2017-00946] Funding Source: Formas
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Proteins in semen, either in spermatozoa (SPZ) or seminal plasma (SP), are directly involved in molecular processes and biological pathways regulating sperm function, including fertilizing ability. Therefore, semen proteins are candidates of choice for biomarkers discovery for fertility and for sperm (dys)function. Mass spectrometry (MS)-based proteomics has opened up a new era for characterizing and quantifying the protein profile of SP and SPZ, as well as for unveiling the complex protein interactions involved in the activation of sperm functionality. This article overviews existing literature on MS-based proteomics regarding porcine semen, with a specific focus on the potential practical application of the results achieved so far. The weaknesses of current studies and the perspectives for future research in MS-based pig semen proteomics are also addressed. (C) 2020 Elsevier Inc. All rights reserved.
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