Journal
TETRAHEDRON LETTERS
Volume 61, Issue 6, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.151470
Keywords
Aza-Michael addition; Chalcones; Graphene oxide; Solvent-free
Categories
Funding
- Shiraz University
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Graphene oxide (GO) in conjunction with tetra n-butyl ammonium bromide (TBAB) was found to function as an efficient catalyst for one-pot sequential aldol coupling/aza-Michael addition of amines to chalcones in a single reaction vessel. Benzaldehydes and acetophenone were coupled in situ to produce their corresponding chalcones which underwent a subsequent aza-Michael addition under solvent-free condition. This procedure avoids the use of precious metals and the heterogeneous nature of the GO simplifies purification and isolation of the products by simple filtration of the catalyst. (C) 2019 Elsevier Ltd. All rights reserved.
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