Journal
TETRAHEDRON
Volume 76, Issue 51, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2020.130967
Keywords
Meldrum's acid; Organozinc reagents; Arylation; Boronic acids
Categories
Funding
- CNPq
- CAPES [001]
- INCT-Catalise
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An approach for the conjugate arylation reaction of unsaturated Meldrum's acid derivatives is reported. The reaction takes place through a Boron-Zinc exchange reaction between arylboronic acids and diethylzinc and the subsequent transfer of thus generated reactive aryl groups to the beta-position of the double bond of the Meldrum's derivatives. The compounds obtained are valuable synthetic intermediates and can give rise to bioactive molecules such as beta,beta-disubstituted carboxylic acids and amides. (C) 2020 Elsevier Ltd. All rights reserved.
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