Journal
TALANTA
Volume 205, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2019.120139
Keywords
Polyoxometalates; Chemiluminescence; Enzyme-like catalysis; H2O2; Blood glucose
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Funding
- National Natural Science Foundation of China [21775017]
- Natural Science Foundation of Jilin Province, China [20180101174JC]
- Jilin Provincial Department of Education and Jilin Provincial Key Laboratory of Micro-Nano Functional Materials (Northeast Normal University)
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We show that vanadomolybdophosphoric heteropoly acid (H5PMo10V2O40, PMoV2), one of the polyoxometalates (POMs), presents peroxidase-like activity that can catalyze the luminol/H2O2 reaction to generate chemiluminescence (CL) emission. Based on this foundation, we report an enzyme-free luminol/H2O2/PMoV2 CL system that can be utilized for the ultrasensitive detection of H2O2. The CL intensity exhibits good linear dependence on H2O2 concentration in a wide range up to 5000 nM with a limit-of-detection of 5 nM. The method was successfully used for the determination of glucose in human serum. Our study paves the way for the application of functional POM materials in a variety of biosensing assays, such as the determination of cholesterol, uric acid, lactate, etc., in which H2O2 is a product of oxidoreductase enzymes.
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