Simultaneous voltammetric determination of Adrenaline and Tyrosine in real samples by neodymium oxide nanoparticles grafted graphene

Nd2O3 nanoparticle grafted graphene nanocomposite (NOGG) was synthesized by sonochemical treatment of an ethanolic dispersion of Nd2O3 nanoparticle and graphene. All the synthesized materials were characterized by XRD, FESEM, TEM, and BET. The NOGG has a high specific surface area (272 m(2)g(-1)) with narrowly distributed pores with diameter centered at 2.8, 6.0 and 7.50 nm. A composite paste electrode of 1:1 (w/w) NOGG and graphite was showed better electrochemical properties. The NOGG/GP electrode showed all around better electrocatalytic activity towards Adrenaline (AD) and Tyrosine (TY) than TRG/GP and bare GP electrode. According to cyclic voltammograms, AD and TY oxidized irreversibly through adsorption control process. DPV peak currents were measured at 378 +/- 15 mV and 787 +/- 15 mV for determination AD and TY respectively using the NOGG/GP electrode as the peak intensities were highest at those potentials. Under the optimized experimental condition, the determination ranges for AD and TY showed two linear ranges, those were 0.1-5-130 mu M and 0.1-3-120 mu M, respectively. A detection limit of AD and TY was measured (m-LOD) to be 50 nM and 40 nM, respectively. The modified electrode was reproducible, selective, highly sensitive and also employed for analysis of AD and TY in biological and pharmaceutical samples with excellent recovery.