Journal
BIOSENSORS & BIOELECTRONICS
Volume 65, Issue -, Pages 108-114Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2014.10.024
Keywords
Molecular imprinted polymers; MIPs; Famciclovir; Computational studies; Carbon paste electrode and cyclic voltammetry
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A molecularly imprinted polymer (MIP) was synthesized and applied as additive within a carbon paste electrode for the cyclic voltammetric determination of famciclovir (FCV). Complementary computational studies were performed to study the intermolecular interactions in the pre-polymerization mixture. Derived from the computational studies, four MIP ratios were synthesized and their performance was evaluated using equilibrium rebinding assays. The MIP with the highest binding capacity was selected. A linear response was obtained in the range of 2.5 x 10(-6)-1.0 x 10(-3) M with a limit of detection at 7.5 x 10(-7) M. Finally, the developed MIP-voltammetry system was successfully applied for the determination of FCV in pure solutions and pharmaceutical preparations. (C) 2014 Elsevier B.V. All rights reserved.
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