Synthesis and application of a molecularly imprinted polymer for the voltammetric determination of famciclovir

A molecularly imprinted polymer (MIP) was synthesized and applied as additive within a carbon paste electrode for the cyclic voltammetric determination of famciclovir (FCV). Complementary computational studies were performed to study the intermolecular interactions in the pre-polymerization mixture. Derived from the computational studies, four MIP ratios were synthesized and their performance was evaluated using equilibrium rebinding assays. The MIP with the highest binding capacity was selected. A linear response was obtained in the range of 2.5 x 10(-6)-1.0 x 10(-3) M with a limit of detection at 7.5 x 10(-7) M. Finally, the developed MIP-voltammetry system was successfully applied for the determination of FCV in pure solutions and pharmaceutical preparations. (C) 2014 Elsevier B.V. All rights reserved.