Journal
SYNTHESIS-STUTTGART
Volume 52, Issue 6, Pages 853-860Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0039-1690763
Keywords
BINOL; C-1-symmetric; substitution; bromination; linking
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Funding
- Fonds der Chemischen Industrie [Li 193/02]
- Evonik Industries AG
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Bis-BINOL derivatives have proven highly useful in applications such as chemosensing or organocatalysis. In this account, we describe strategies for the linking of BINOL units via the 3-, 4-, or 5-positions, showing that unique synthetic strategies are necessary to address each position. We report the synthesis of suitable C-1-symmetric precursors, which are generated either by monohalogenation or by monodeprotection of C-2-symmetric starting materials, and their subsequent coupling to give linked bis-BINOL derivatives.
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