Journal
SYNLETT
Volume 31, Issue 9, Pages 878-882Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1707968
Keywords
green chemistry; water catalysis; hydroamination; alkynes; enamines
Categories
Funding
- National Natural Science Foundation of China [21602085, 51902140]
- Natural Science Foundation of Jiangsu Province [BK20160551]
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A green H2O-promoted solvent-free hydroamination of electron-deficient terminal alkynes with amines has been developed. All secondary amines, including aliphatic and aromatic amines, gave the corresponding (E)-enamines in good to excellent yields, whereas primary aromatic amines afforded Z-configured products in moderate yields. Propiolates, propyn-1-ones, propynamides, and 1-(ethynylsulfonyl)-4-methylbenzene were explored in this Michael addition.
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