Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 224, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2019.117410
Keywords
Fluorescent probe; Julolidine-coumarinocoumarin; Ultrafast; Hydrogen polysulfides (H2Sn, n>1); Zebra fish
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Funding
- National Natural Science Foundation of China [U1608222]
- Fundamental Research Funds for the Central Universities [202045010]
- State Key Laboratory of Fine Chemicals [KF1606]
- State Key Laboratory of Chemo/Biosensing and Chemometrics [2016005]
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Hydrogen polysulfides (H2Sn, n>1) plays crucial roles in many biological processes, while it remains a challenge for rapid and selective detection of H2Sn. We designed and synthesized a turn-on fluorescent probe (JCCF) for detecting H2Sn based on a new julolidine-coumarinocoumarin scaffold. H2Sn could trigger a dramatic fluorescence enhancement (52-fold) with a fast response time and a low detection limit of 98.3 nM (S/N = 3). Moreover, JCCF was successfully applied to image H2Sn in living cells and zebra fish with low cytotoxicity. (C) 2019 Elsevier B.V. All rights reserved.
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