Journal
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Volume 77, Issue 3, Pages 485-494Publisher
SPRINGER
DOI: 10.1007/s00280-015-2957-7
Keywords
Model-based meta-analysis; Docetaxel; Non-small-cell lung cancer; Dose-response
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Funding
- F. Hoffmann-La Roche Ltd., Basel, Switzerland
- Genentech, Inc., Roche Group, South San Francisco, CA, USA
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To gain a better understanding of the impact of dose and other prognostic factors on safety and efficacy of docetaxel in second-line non-small-cell lung cancer patients. A model-based metaaEuroanalysis (MBMA) of a published docetaxel monotherapy data in 6085 secondaEuroline non-small-cell lung cancer patients from 46 trials was conducted. The logit of grade 3/4 neutropenia incidence was a linear function of dose, with a 5 % increase in the odds of neutropenia per mg/m(2) increase in dose [odds ratio (OR) 1.05, 95 % confidence interval (CI) 1.04-1.06], and a Japanese study effect (OR 17.1, 95 % CI 6.05-48.4). The logit of overall response rate (ORR) was a linear function of cumulative dose (0.4 % increase in the odds of response per mg/m(2) increase; OR 1.004, 95 % CI 1.001-1.008) and median population age (OR 1.08 per year, 95 % CI 1.02-1.15). A Japanese study effect was identified for overall survival (OS) in addition to prognostic factors identified by a previous meta-analysis. This current MBMA identified docetaxel dose-response relationships for both neutropenia and ORR, an effect of age on ORR, and Japanese study effects on both neutropenia and OS.
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