Journal
CANCER CELL
Volume 29, Issue 1, Pages 5-16Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2015.12.003
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Funding
- NIH [CA-096832, CA-21765]
- Deutsche Forschungsgemeinschaft [222/12-1]
- German Excellence Initiative via the Graduate School of Life Sciences (University of Wurzburg)
- Cancer Center Development Funds [CA021765]
- Sontag Foundation Distinguished Scientist Award
- Sununu Fellowship
- Anderson Fellowship
- American Lebanese Syrian Charities of St. Jude Children's Research Hospital
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Four distinct subgroups of cerebellar medulloblastomas (MBs) differ in their histopathology, molecular profiles, and prognosis. c-Myc (Myc) or MycN overexpression in granule neuron progenitors (GNPs) induces Group 3 (G3) or Sonic Hedgehog (SHH) MBs, respectively. Differences in Myc and MycN transcriptional profiles depend, in part, on their interaction with Miz1, which binds strongly to Myc but not MycN, to target sites on chromatin. Myc suppresses ciliogenesis and reprograms the transcriptome of SHH-dependent GNPs through Miz1-dependent gene repression to maintain stemness. Genetic disruption of the Myc/Miz1 interaction inhibited G3 MB development. Target genes of Myc/Miz1 are repressed in human G3 MBs but not in other subgroups. Therefore, the Myc/Miz1 interaction is a defining hallmark of G3 MB development.
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