Journal
CANCER CELL
Volume 30, Issue 1, Pages 120-135Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2016.06.001
Keywords
-
Categories
Funding
- Department of Defense [LC140199]
- NIH [RO1 CA187392-01A1, R01 CA193556, K12CA076931]
- Lung Cancer Translation Center of Excellence of the Abramson Cancer Center at the University of Pennsylvania
Ask authors/readers for more resources
Based on studies in mouse tumor models, granulocytes appear to play a tumor-promoting role. However, there are limited data about the phenotype and function of tumor-associated neutrophils (TANs) in humans. Here, we identify a subset of TANs that exhibited characteristics of both neutrophils and antigen-presenting cells (APCs) in early-stage human lung cancer. These APC-like hybrid neutrophils, which originate from CD11b(+)CD15(hi)CD10(-)CD16(low) immature progenitors, are able to cross-present antigens, as well as trigger and augment anti-tumor T cell responses. Interferon-g and granulocyte-macrophage colony-stimulating factor are requisite factors in the tumor that, working through the Ikaros transcription factor, synergistically exert their APC-promoting effects on the progenitors. Overall, these data demonstrate the existence of a specialized TAN subset with anti-tumor capabilities in human cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available