Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 307, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2019.127634
Keywords
Surface-enhanced raman scattering; ZnO/Ag nanorods; Synergistic charge transfer effect; Oral antidiabetic drugs; Simultaneous detection
Funding
- Fundamental Research Funds for the Central Universities
- Natural Science Foundation of Gansu Province, China [17JR5RA209]
- National Natural Science Foundation of China [81772907]
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It is popular and promising to explore a prominent surface-enhanced Raman scattering (SERS) substrate for simultaneous determination of multiple analytes in drug safety and quality monitoring. To achieve the goal, in this work, we constructed a plasmonic metal/semiconductor oxide heterostructure by depositing Ag nanoparticles (NPs) on ZnO nanorods. The ZnO/Ag substrate exhibited prominent SERS performance by using rhodamine 6 G as the probe molecule, including transferable nature onto various available substrate, high enhancement factor, stability and uniformity. The synergistic charge transfer effect was systematically studied, including the effects of the Ag loading amount and laser wavelength, photoluminescence, UV-vis spectra and XPS analysis. The ZnO/Ag substrate was developed as a SERS probe for separate and simultaneous detection of two oral antidiabetic drugs (OADs), pioglitazone (PIO) and phenformin (PHE) in human urine. The detection limits were as low as 1 and 5 nM for PIO and PHE (respectively) with good selectivity and satisfactory recoveries. This type of SERS substrate will be suitable for rapid and noninvasive determination of OADs in clinic applications.
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