4.7 Article

Smartphone-based tape sensors for multiplexed rapid urinalysis

Journal

SENSORS AND ACTUATORS B-CHEMICAL
Volume 304, Issue -, Pages -

Publisher

ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2019.127415

Keywords

Tape; Urine; Urinalysis; Colorimetric sensor array

Funding

  1. National Natural Science Foundation of China [21804007, 21890742]
  2. Beijing Natural Science Foundation [2184109]
  3. Fundamental Research Funds for Central Universities [FRF-TP-17-066A1, FRF-BR-18-009B]
  4. National Postdoctoral Innovative Talents Support Program of China [BX20180036]
  5. China Postdoctoral Science Foundation [2019M650479]

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Recent advances in biofluids monitoring have positioned urine as a non-invasive candidate for clinical diagnosis. In this paper, we employ adhesive tapes with indicator-functionalized microarrays for rapid urinalysis. Such tape-based sensor combines advantages of flexibility, adhesive and waterproof functionality in a platform, which is simply prepared by physical punching, fabrics filling and indicators modification. The simulated urine flow can be captured and penetrated in the tape-based microarrays for rapid detection of multiplexed markers such as glucose, nitrite, protein and phenylpyruvate with a smartphone-assisted colorimetric screening method. As a user-friendly point-of-care testing (POCT) approach, such tape-based sensor is ideally favorable for the early disease warning toward the patients of urinary incontinence and infants.

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