Journal
CANCER CELL
Volume 29, Issue 6, Pages 776-778Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2016.05.014
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Prostate cancer is lethal when tumors evolve to activate androgen receptor signaling, which circumvents ligand-deprivation therapy. In this issue of Cancer Cell, Groner et al. show that histone reader and transcription co-regulator TRIM24 occupies a central role in this evolution, nominating inhibitors of TRIM24's bromodomain as a new therapeutic avenue.
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