Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 304, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2019.127300
Keywords
Endotoxin; OFF-ON; Aggregation induced emission (AIE); Specific peptide for LPS; Clearance of bacterial endotoxin
Funding
- National Natural Science Foundation of China [81573388]
- Six talent peaks project of Jiangsu Province [YY-032]
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Endotoxin, also known as lipopolysaccharide (LPS), can induce strong immune response that causes casualties annually. This number may be greatly reduced if specific, robust, sensitive and more capable of clearance LPS biosensor existed. By introducing a LPS specific binding peptide to a typical aggregation induced emission (AIE) fluorophore, 1-(4-carboxylbenzene)-1,2,2-triphenyl (CTPY), a robust, sensitive and specific OFF-ON fluorescent biosensor was developed. The biosensor can achieve LPS sensing of a linear relationship in the concentration range of 0.1-1 mu M with a detection limit of 6.97 nM. Moreover, a rapid clearance of LPS is simultaneous realized by integration of mesoporous silica nanospheres with a LPS recognition peptide. Such robust biosensor with highly specific detection and rapid clearance based on LPS specific binding peptide hold considerable promise in diverse clinical and biological applications.
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