Journal
CANCER CELL
Volume 30, Issue 4, Pages 505-507Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2016.09.012
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In this issue of Cancer Cell, Ferone et al. demonstrate that SOX2 not only drives lung tumor formation but also restricts tumor lineage to squamous cell carcinoma (LSCC), regardless of cell of origin. This novel LSCC model should facilitate identification of key oncogenic drivers and treatment strategies for this lung cancer subtype.
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