Journal
BIOSENSORS & BIOELECTRONICS
Volume 68, Issue -, Pages 494-499Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2015.01.040
Keywords
Peptide; Graphene oxide; Biosensor; Optical detection; Explosive
Categories
Funding
- National Natural Science Foundation of China [81371643]
- Zhejiang Provincial Natural Science Foundation of China [LR13H180002]
- Research on Public Welfare Technology Application Projects of Zhejiang Province [2014C33149]
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A label-free optical biosensor was constructed with biofunctionalized graphene oxide (GO) for specific detection of 2,4,6-trinitrotoluene (TNT). By chemically binding TNT-specific peptides with GO, the biosensor gained unique optoelectronic properties and high biological sensitivity, with transducing bimolecular bonding into optical signals. Through UV absorption detection, increasing absorbance responses could be observed in presence of TNT at different concentrations, as low as 4.40 x 10(-9) mM, and showed dose-dependence and stable behavior. Specific responses of the biosensor were verified with the corporation of 2,6-dinitrotoluene (DNT), which had similar molecular structure to TNT. Thus, with high sensitivity and selectivity, the biosensor provided a convenient approach for detection of explosives as miniaturizing and integrating devices. (C) 2015 Elsevier B.V. All rights reserved.
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