Journal
BIOSENSORS & BIOELECTRONICS
Volume 65, Issue -, Pages 232-237Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2014.10.046
Keywords
Poly(diallyldimethyl ammonium chloride); Gold nanoparticles; Graphene; Aptamer; Electrochemical; Angiogenin
Categories
Funding
- Natural Natural Science Foundation of China [21371123]
- Scientific Research Project of Beijing Educational Committee [KM201410028006]
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Herein, a label-free and highly sensitive electrochemical aptasensor for the detection of angiogenin was proposed based on a conformational change of aptamer and amplification by poly(diallyldimethyl ammonium chloride) (PDDA)-functionalized graphene/gold nanoparticles (AuNPs) composites-modified electrode. PDDA-functionalized graphene (P-GR) nanosheets as the building block in the self-assembly of GR nanosheets/AuNPs heterostructure enhanced the electrochemical detection performance. The electrochemical aptasensor has an extraordinarily sensitive response to angiogenin in a linear range from 0.1 pM to 5 nM with a detection limit of 0.064 pM. The developed sensor provides a promising strategy for the cancer diagnosis in medical application in the future. (C) 2014 Elsevier B.V. All rights reserved.
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