Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 25, Issue 2, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2020.101080
Keywords
Infant; Extremely premature; Pulse oximetry; Randomized controlled trial; Individual participant data meta-analysis
Categories
Funding
- Canadian Institutes of Health Research [MCT-79217]
Ask authors/readers for more resources
The Neonatal Oxygenation Prospective Meta-analysis combined the individual participant data of 4965 extremely preterm infants. They had been randomly assigned in 5 trials to arterial oxygen saturations of 85%-89% or 91%-95% using modified oximeters to mask the treatment allocation. The primary outcome of death or disability did not differ significantly between the groups. Assignment to the higher target range reduced the risks of death and severe necrotizing enterocolitis but increased the risk of treated retinopathy. Trade-offs between the benefits and risks of higher or lower saturation targets should be informed by the local patient risks and institutional rates for outcomes that may be affected by a policy change. Features of the oximeter masking algorithm introduced unanticipated artifacts into the saturation display that are not seen in routine care. NeOProM provides little guidance on where to set the oximeter alarms and how to respond to them.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available