Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 101, Issue -, Pages 59-67Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2020.01.007
Keywords
Helicobacter pylori; Autophagy; Virulence factor; Intracellular survival
Categories
Funding
- Taiwan Ministry of Science and Technology [MOST108-2811B-007-507, 108-2321-B007-004, 107-2627-M-007-004, 106-2320B-182-012-MY3]
- Chang Gung Memorial Hospital [CMRPD1I0061-3, CMRPD1J0021-3, BMRPE90]
- Tomorrow Medical Foundation
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Helicobacter pylori colonizes human stomach mucosa and its infection causes gastrointestinal diseases with variable severity. Bacterial infection stimulates autophagy, which is a part of innate immunity used to eliminate intracellular pathogens. Several intracellular bacteria have evolved multipronged strategies to circumvent this conserved system and thereby enhance their chance of intracellular survival. Nonetheless, studies on H. pylori have produced inconsistent results, showing either elevated or reduced clearance efficiency of intracellular bacteria through autophagy. In this review, we summarize recent studies on the mechanisms involved in autophagy induced by H. pylori and the fate of intracellular bacteria.
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