Journal
CANCER AND METASTASIS REVIEWS
Volume 35, Issue 4, Pages 655-667Publisher
SPRINGER
DOI: 10.1007/s10555-016-9650-0
Keywords
Extracellular matrix (ECM); Breast cancer; Desmoplasia; Mechanosignaling; Metastasis; Treatment resistance
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Funding
- NIH [RO1CA192914]
- USMRAA (DOD) [BC122990]
- U54 grant [CA210184]
- UO1 grant [CA202241-01]
- CDMRP [BC122990, 542337] Funding Source: Federal RePORTER
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The extracellular matrix (ECM) is a guiding force that regulates various developmental stages of the breast. In addition to providing structural support for the cells, it mediates epithelial-stromal communication and provides cues for cell survival, proliferation, and differentiation. Perturbations in ECM architecture profoundly influence breast tumor progression and metastasis. Understanding how a dysregulated ECM can facilitate malignant transformation is crucial to designing treatments to effectively target the tumor microenvironment. Here, we address the contribution of ECM mechanics to breast cancer progression, metastasis, and treatment resistance and discuss potential therapeutic strategies targeting the ECM.
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