Journal
SCIENCE OF THE TOTAL ENVIRONMENT
Volume 702, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.scitotenv.2019.134994
Keywords
Nanomaterials; Mitochondria; Mitochondrial toxicity; Mitochondrial dynamic; Mitochondrial homeostasis
Categories
Funding
- National Natural Science Foundation of China [81673218]
- Fundamental Research Funds for the Central Universities [2242019K40223]
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In recent years, nanomaterials have been widely applied in electronics, food, biomedicine and other fields, resulting in increased human exposure and consequent research focus on their biological and toxic effects. Mitochondria, the main target organelle for nanomaterials (NM), play a critical role in their toxic activities. Several studies to date have shown that nanomaterials cause alterations in mitochondrial morphology, mitochondrial membrane potential, opening of the mitochondrial permeability transition pore (MPTP) and mitochondrial respiratory function, and promote cytochrome C release. An earlier mitochondrial toxicity study of NMs additionally reported induction of mitochondrial dynamic changes. Here, we have reviewed the mitochondrial toxicity of NMs and provided a scientific basis for the contribution of mitochondria to the toxicological effects of different NMs along with approaches to reduce mitochondrial and, consequently, overall toxicity of NMs. (C) 2019 Elsevier B.V. All rights reserved.
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