Journal
SCIENCE
Volume 367, Issue 6476, Pages 453-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaw1965
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Funding
- European Research Council under the European Union [337635]
- Institut Pasteur
- CNRS
- Cercle FSER
- Fondation pour la Recherche Medicale
- Vallee Foundation
- European Research Council (ERC) [337635] Funding Source: European Research Council (ERC)
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Tissue morphogenesis is driven by local cellular deformations that are powered by contractile actomyosin networks. How localized forces are transmitted across tissues to shape them at a mesoscopic scale is still unclear. Analyzing gastrulation in entire avian embryos, we show that it is driven by the graded contraction of a large-scale supracellular actomyosin ring at the margin between the embryonic and extraembryonic territories. The propagation of these forces is enabled by a fluid-like response of the epithelial embryonic disk, which depends on cell division. A simple model of fluid motion entrained by a tensile ring quantitatively captures the vortex-like polonaise movements that accompany the formation of the primitive streak. The geometry of the early embryo thus arises from the transmission of active forces generated along its boundary.
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