Web-based collaborative care intervention to manage cancer-related symptoms in the palliative care setting

BACKGROUNDThe aim of this study was to examine the efficacy of a collaborative care intervention in reducing depression, pain, and fatigue and improve quality of life. METHODSA total of 261 patients with advanced cancer and 179 family caregivers were randomized to a web-based collaborative care intervention or enhanced usual care. The intervention included the following: 1) a web site with written and audiovisual self-management strategies, a bulletin board, and other resources; 2) visits with a care coordinator during a physician's appointment every 2 months; and 3) telephone follow-up every 2 weeks. Primary patient outcomes included measures of depression, pain, fatigue, and health-related quality of life. Secondary outcomes included Interleukin (IL)-1, IL-1, IL-6, and IL-8 levels, Natural Killer (NK) cell numbers, and caregiver stress and depression. RESULTSAt the baseline, 51% of the patients reported 1 or more symptoms in the clinical range. For patients who presented with clinical levels of symptoms and were randomized to the intervention, reductions in depression (Cohen's d = 0.71), pain (Cohen's d = 0.62), and fatigue (Cohen's d = 0.26) and improvements in quality of life (Cohen's d = 0.99) were observed when compared to those in the enhanced usual car arm at 6 months. Reductions in IL-6 ( = 0.18), IL-1 ( = 0.35), IL-1 (phi = 0.19), and IL-8 (phi = 0.15) and increases in NK cell numbers (phi = 0.23) were observed in comparison with enhanced usual care arm at 6 months. Reductions in caregiver stress (Cohen's d = 0.75) and depression (Cohen's d = 0.37) were observed at 6 months for caregivers whose loved ones were randomized to the intervention arm. CONCLUSIONSThe integration of screening and symptom management into cancer care is recommended. Cancer 2016;122:1270-82. (c) 2016 American Cancer Society. A stepped web-based collaborative care intervention reduces symptoms, improves quality of life, and decreases inflammation for patients receiving palliative care for cancer. Furthermore, the intervention reduces caregiver stress and depression.