Journal
RUSSIAN CHEMICAL BULLETIN
Volume 68, Issue 12, Pages 2216-2224Publisher
SPRINGER
DOI: 10.1007/s11172-019-2690-1
Keywords
oxidative stress; reactive oxygen species; ascorbic acid; human cancer cells; (FeCl)-Cl-III tetraphenylporphyrin; polymer particles; copolymer of lactic and glycolic acids
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Funding
- Russian Foundation for Basic Research [17-04-01009\19]
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Reactive oxygen species are generated by the redox reaction involving metalloporphyrin and ascorbic acid (AA) and lead to oxidative stress followed by cancer cell death. Polymer particles based on the copolymer of lactic and glycolic acid (PLGA) containing (FeCl)-Cl-III-tetraphenylporphyrin (FeClTPP) were prepared and characterized. These particles in combination with AA exhibit cytotoxic activity against the K562 (human chronic myelogenous leukemia) and MCF7 (human breast adenocarcinoma) cell lines. Results in vitro indicated significant antitumor efficiency on mice inoculated with P388 leukemic cells and treated with FeClTPP/AA. The cytotoxic activity of the combined system is achieved due to the formation of reactive oxygen species. The application of this system to the study of anticancer efficiency in vivo on the model of mice that were hypodermically inoculated with P388 lymphocytic leukemia revealed a significant inhibition of tumor growth. The use of FeClTPP in combination with AA seems to be promising in cancer treatment.
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