Journal
RNA BIOLOGY
Volume 17, Issue 11, Pages 1523-1534Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2019.1702283
Keywords
Long non-coding RNA; ovarian cancer; oncogene; tumour suppressor; diagnosis; therapeutics; biomarker
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Funding
- 2219-Research Grant as part of the International Postdoctoral Research Scholarship Program of Scientific and Technological Research Council of Turkey (TUBITAK)
- NIH through the Ovarian SPORE Career Enhancement Program
- NCI [P50 CA217685, U01 CA213759, P50 CA098258, R35 CA209904]
- American Cancer Society Research Professor Award
- Judy's Mission
- Frank McGraw Memorial Chair in Cancer Research
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Long non-coding RNAs (lncRNAs), initially recognized as byproducts of the transcription process, have been proven to play crucial modulatory roles in preserving overall homoeostasis of cells and tissues. Furthermore, aberrant levels of these transcripts have been shown to contribute many diseases, including cancer. Among these, many aspects of ovarian cancer biology have been found to be regulated by lncRNAs, including cancer initiation, progression and dissemination. In this review, we summarize recent studies to highlight the various roles of lncRNAs in ovary in normal and pathological conditions, immune system, diagnosis, prognosis, and therapy. We address lncRNAs that have been extensively studied in ovarian cancer and their contribution to cellular dynamics.
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