Journal
RNA BIOLOGY
Volume 17, Issue 5, Pages 743-754Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2020.1728102
Keywords
miR-208b; TCF12; FNIP1; skeletal muscle development; energy homeostasis
Categories
Funding
- National Natural Science Foundation of China [31672391, 31802042]
- National Transgenic Project of China [2016ZX08006003-004]
- Fund of Modern Industrial Technology System of Pig [CARS-35]
Ask authors/readers for more resources
Embryonic and neonatal skeletal muscles grow via the proliferation and fusion of myogenic cells, whereas adult skeletal muscle adapts largely by remodelling pre-existing myofibers and optimizing metabolic balance. It has been reported that miRNAs played key roles during skeletal muscle development through targeting different genes at post-transcriptional level. In this study, we show that a single miRNA (miR-208b) can modulate both the myogenesis and homoeostasis of skeletal muscle by distinct targets. As results, miR-208b accelerates the proliferation and inhibits the differentiation of myogenic cells by targeting the E-protein family member transcription factor 12 (TCF12). Also, miR-208b can stimulate fast-to-slow fibre conversion and oxidative metabolism programme through targeting folliculin interacting protein 1 (FNIP1) but not TCF12 gene. Further, miR-208b could active the AMPK/PGC-1a signalling and mitochondrial biogenesis through targeting FNIP1. Thus, miR-208b could mediate skeletal muscle development and homoeostasis through specifically targeting of TCF12 and FNIP1.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available