Journal
CANCER
Volume 122, Issue 12, Pages 1809-1821Publisher
WILEY
DOI: 10.1002/cncr.29841
Keywords
carcinogenesis; neoplasm; radiotherapy; risk; second primary; survivors
Categories
Funding
- National Institutes of Health [R21 167800]
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Radiation has long been associated with carcinogenesis. Nevertheless, it is an important part of multimodality therapy for many malignancies. It is critical to assess the risk of secondary malignant neoplasms (SMNs) after radiation treatment. The authors reviewed the literature with a focus on radiation and associated SMNs for primary hematologic, breast, gynecologic, and pediatric tumors. Radiation appeared to increase the risk of SMN in all of these; however, this risk was found to be associated with age, hormonal influences, chemotherapy use, environmental influences, genetic predisposition, infection, and immunosuppression. The risk also appears to be altered with modern radiotherapy techniques. Practitioners of all specialties who treat cancer survivors in follow-up should be aware of this potential risk. Cancer 2016;122:1809-21. (c) 2016 American Cancer Society. Radiation appears to increase the risk of developing secondary neoplasms. This risk appears to be altered by multiple factors.
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