Journal
RESEARCH IN VETERINARY SCIENCE
Volume 128, Issue -, Pages 16-23Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2019.10.005
Keywords
Pseudorabies; Variant pseudorabies virus; Bartha-K61 vaccine; rPRV-gI(-)/gE(-)/TK- prototype vaccine; Efficacy
Categories
Funding
- National Key RD Program [2016YFD0500704-2]
- Novel Agricultural Research Program of Jiangsu Province [SXGC[2017] 231]
- earmarked fund for Jiangsu Agricultural Industry Technology System [JATS[2018]221]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Science and Technology Support Program of Jiangsu Province [BE2014355]
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Pseudorabies has caused huge economic losses in China's pig industry and recurred on many large pig farms since late 2011. The disease is caused by highly pathogenic, antigenic variant pseudorabies virus (vPRV) strains. Therefore, the prevention and control of this recurrence of pseudorabies in China has been given priority. In a previous study, we showed that a suitable dose [1 x 10(6.3) 50% tissue culture infectious dose (TCID50) per animal] of commercial Bartha-K61 vaccine protects growing pigs against lethal challenge by the emerging vPRV strain XJ5. In this study, different doses of the Bartha-K61 vaccine and our newly developed rPRV-gl(-)/gE(-)/TK- ( )prototype vaccine derived from the vPRV strain XJ5 were used to evaluate immune protection against sublethal challenge by the vPRV strain XJ5. Pigs vaccinated with high doses of the Bartha-K61 vaccine or rPRV-gl(-)/gE(-)/TK- prototype vaccine showed no differences in their humoral immune responses, clinical symptoms, body weight gains, viral shedding, or gross and histological lesions after sublethal challenge by the vPRV strain XJ5. Therefore, we concluded that the Bartha-K61 vaccine at a dose of 1 x 10(5) TCID50 per animal protects pigs against sublethal challenge by the vPRV strain XJ5 and performs equally well as the same dose of the rPRV-gl(-)/gE(-)/TK- vaccine, whereas lower doses of the Bartha-K61 vaccine alone do not protect pigs from this challenge. These findings provide useful information for vaccination interventions and the ultimate eradication of pseudorabies caused by vPRV strains emerging in China.
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