Journal
REPRODUCTIVE TOXICOLOGY
Volume 90, Issue -, Pages 8-14Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2019.08.003
Keywords
ALSPAC; Endocrine disruptors; Perfluoroalkyl substances; Gestational weight gain; Perfluorooctanoic acid (PFOA); Perfluorooctane sulfonic acid (PFOS); Perfluorohexane sulfonic acid (PFHxS); Perfluorononanoic acid (PFNA)
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Funding
- UK Medical Research Council [102215/2/13/2]
- Wellcome Trust [102215/2/13/2]
- Centers for Disease Control and Prevention [AY5350]
- UK MRC [MR/M009351/1]
- MRC [MC_UU_00011/6, MR/M009351/1, MC_PC_19009] Funding Source: UKRI
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Perfluoroalkyl substances (PFAS) are chemicals used in the manufacture of consumer products. PFAS may act as endocrine disruptors, influencing metabolic pathways and weight-related outcomes. Previous studies observed an association between perfluorooctane sulfonic acid (PFOS) and higher gestational weight gain among under-/normal weight mothers. We analyzed associations of maternal serum pregnancy concentrations of PFAS with gestational weight gain (GWG) using data from 905 women in a subsample of the Avon Longitudinal Study of Parents and Children. Women were routinely weighed in antenatal check-ups; absolute GWG was determined by subtracting the first weight measurement from the last. Linear regression was used to explore associations of maternal PFAS concentrations with absolute GWG, stratified by prepregnancy body mass index. Associations of maternal PFOS, perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) concentrations with absolute GWG were null; 10% higher PFOS was associated with GWG of -0.03 kg (95% CI: -0.11, 0.06) among under-/normal weight mothers. Ten percent higher perfluorononanoic acid (PFNA) was associated with a higher GWG of 0.09 kg (95% CI: 0.02, 0.16) among under-/normal weight mothers. Overall, findings suggest no association between maternal PFOA, PFOS, and PFHxS concentrations and GWG, and a weak positive association between maternal PFNA and GWG.
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