Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 296, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2019.111021
Keywords
Alzheimer's disease; Neuroimaging; False memory; Confabulation
Categories
Funding
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
Ask authors/readers for more resources
Alzheimer's disease (AD) is characterised by episodic memory impairment, but people also experience memory distortions, including false memories, which can impact on safety and reduce functioning. Understanding the neural networks that underpin false memories could help to predict the need for intervention and guide development of cognitive strategies to reduce memory errors. However, there is a relative absence of research into how the neuropathology of AD contributes to false memory generation. This paper systematically reviews the methodology and outcomes of studies investigating the neuroimaging correlates of false memory in AD. Four studies using structural imaging and three studies using functional imaging were identified. Studies were heterogenous in methodology and received mostly 'weak' quality assessment ratings. Combined, and consistent with neuroimaging findings in non-AD populations, results from identified studies provide preliminary support for the hypothesis that medial temporal lobe and prefrontal cortex dysfunction may lead to generation of false memories in AD. However, the small number of studies and significant heterogeneity within them means further study is necessary to assess replicability of results.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available