Journal
PSYCHIATRY INVESTIGATION
Volume 17, Issue 1, Pages 9-20Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
DOI: 10.30773/pi.2019.0112
Keywords
Heart rate variability; Posttraumatic stress disorder; Endophenotype; Meta-analysis
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Funding
- Special Project on Natural Chronic Non-infectious Diseases [2016YFC1307201]
- National Natural Science Foundation of China [81701328, 81871061, 81371484]
- National Key Research & Development Program of China [2016YFC1307200]
- China Postdoctoral Science Foundation [2017M612972]
- Postdoctoral Foundation of Sichuan University [2018SCU12042]
- Department of Science & Technology of Sichuan Province [2018 SZ0131]
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Objective The functions of both the central and peripheral autonomic nervous system, indexed by heart rate variability (HRV), are affected by psychology and physiology This review summarizes the results of studies comparing the evaluation of HRV parameters between individuals with posttraumatic stress disorder (PTSD) and healthy controls. Methods Eligible studies (11=499) were identified through literature searches of the EMBASE, Medlin, PubMed and Web of Science databases. Nineteen studies met our inclusion criteria. A random effects model was used, and standardized mean differences for high-frequency HRV(HF-I IRV), low-frequency HRV(LF-HRV) and the root mean square of successive R-R interval differences (RMSSD) were calculated. Results Significant effects were found for HF-HRV [p<0.0001, Z=4.18; Hedges'g=-1.58, 95% confidence interval (CI) (-2.32, -0.84); k=14] and RMSSD [p<0.00001, Z=4.80; Hedges'g -1.96, 95% CI (-2.76, -1.16); k=9] relative to healthy controls. Considerable heterogeneity was revealed, but the main effects for HF-HRV and RMSSD were robust in subsequent meta-regression and subgroup analyses. Conclusion Given the relationships among low vagal gate, inflammation, and alterations in brain structure and function, including executive function and emotion regulation, reduced HRV may be regarded as an endophenotype in PTSD research.
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